王帅（1988.01），ok138太阳集团副教授、硕士生导师。2016年7月毕业于中国林业科学研究院林业研究所，获博士学位；2022年12月于中国医学科学院药物研究所完成博士后研究；2025年赴德国格赖夫斯瓦尔德大学完成访问学者研修。主要从事工业酶工程改造、天然产物生物合成途径解析、医药中间体工程菌株构建等方向研究。主持山东省科研项目2项，发表SCI论文10余篇，申请发明专利2项。

 

主持的科研项目：

基于进化酶工程的生物质副产物定向转化制备光学纯樟脑研究，2026.01-2028.12，在研。

粗榧中类紫杉二烯合酶CsTSL的功能研究及产物决定性氨基酸残基的挖掘， 2019.07-2023.06，已结题。

 

近五年发表的论文：

1. Wang, S. , He, J. N. , Wang, Y. J. , Zhao, W. Y. , Yang, Q. X. , & Wang, Y. N. , et al. (2025). Metabolome and genome analysis of a novel endophytic fungus aureobasidium pullulans kb3: discovery of polyketones and polyketone biosynthesis pathway. Biochemical Genetics, 63(4).

2. Guo, A., Liu, J., Li, C., Wang, S., Han, Y., Sui, S., ... & Dai, J. (2025). Four Cytochrome P450 Enzymes Mediate Oxidation Cascades in the Biosynthesis of Cephalotane‐Type Diterpenoids. Angewandte Chemie, 137(51), e202512854.

3. Li, C., Yin, X., Wang, S., Sui, S., Liu, J., Sun, X., ... & Dai, J. (2024). A cytochrome P450 enzyme catalyses oxetane ring formation in paclitaxel biosynthesis. Angewandte Chemie International Edition, 63(31), e202407070.

4. Li, C.^#, Wang, S.^#*, Yin, X., Guo, A., Xie, K., Chen, D., ... & Dai, J. * (2023). Functional Characterization and Cyclization Mechanism of a Diterpene Synthase Catalyzing the Skeleton Formation of Cephalotane‐Type Diterpenoids. Angewandte Chemie, 135(33), e202306020.

5. Wang, R., Dong, L., Chen, Y., Wang, S., & Qu, L. (2022). Third generation genome sequencing reveals that endobacteria in Nematophagous fungi Esteya vermicola contain multiple genes encoding for Nematicidal proteins. Frontiers in Microbiology, 13, 842684.

6. Jiang, L., Zhang, K., Lü, X., Yang, L., Wang, S., Chen, D., ... & Qiu, D. (2021). Characterization and expression analysis of genes encoding Taxol biosynthetic enzymes in Taxus spp. Journal of Forestry Research, 32(6), 2507-2515.

7. Shi, S., Cheng, Y., Wang, S., Zhang, X., Han, F., Li, X., & Dong, H. (2023). Improvement of the conjugation transfer of N. gerenzanensis based on the synergistic effect of quorum sensing and antibiotic interference. AMB Express, 13(1), 133.

8. Yan, B., Gao, W., Tian, L., Wang, S., & Dong, H. (2022). Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain. Biotechnology Letters, 44(2), 259-269.